Kidney disease in cats: High-quality feline iPSCs generated without genetic footprint
High-quality feline induced pluripotent stem cells (iPSCs) have now been generated. The feline iPSCs are also footprint- and feeder-free. Further research using these stem cells is expected to elucidate the pathogenesis of cats' chronic kidney disease and develop therapeutic agents.
Stem Cells News -- ScienceDailyBlood stem cell breakthrough could transform bone marrow transplants
Researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia and bone marrow failure disorders.
Benefits and downside of fasting
Researchers identified a signaling pathway in mice that boosts intestinal stem cells' regeneration abilities after fasting. When cancerous mutations occurred during this regenerative period, mice were more likely to develop early-stage intestinal tumors.
Surprising mechanism for removing dead cells identified
A tandem signaling process turns ordinary cells into an efficient cleanup crew.
DNA replication mechanism in pluripotent stem cells
Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic replication stress. However, a recent report challenges this assumption by providing a detailed molecular investigation of replication dynamics in these cells.
Scientists discover breakthrough method to activate dormant stem cells in the brain
Scientists have discovered a novel pathway to wake up dormant neural stem cells, offering potential new therapies for neurodevelopmental disorders such as autism, learning disabilities, and cerebral palsy.
Exciting advance in stem cell therapy
A new technique for mechanically manipulating stem cells could lead to new stem cell treatments, which have yet to fulfill their therapeutic potential.
NK cells expressing interleukin-21 show promising antitumor activity in glioblastoma cells
Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according to new research.
Potential new approach to enhancing stem-cell transplants
A discovery may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.
Viral defense protein speeds up female stem cell production
A viral defense mechanism can be used to accelerate the creation of female stem cell lines in mice. The findings can boost efforts in medical research, drug testing, and regenerative therapies, particularly for women and individuals with two X chromosomes.
Scientists create a cell that precludes malignant growth
Researchers succeeded in creating cells whose proliferation can be controlled. The technique enables new and safe cell therapies.
Human cells for cardiovascular research
The innermost layer of blood vessels is formed by endothelial cells, which in turn play a role in the development of diseases of the cardiovascular system. Human endothelial cells are therefore required for the 'in vitro' investigation of the causes of these diseases. Researchers have now established a highly efficient, cost-effective and reproducible way to generate functional endothelial cells from human induced pluripotent stem cells (hiPSCs) for tests in cell culture dishes.
Fighting leukemia by targeting its stem cells
Acute myeloid leukemia is one of the deadliest cancers. Leukemic stem cells responsible for the disease are highly resistant to treatment. A team has made a breakthrough by identifying some of the genetic and energetic characteristics of these stem cells, notably a specific iron utilization process. This process could be blocked, leading to the death or weakening of these stem cells without affecting healthy cells. These results pave the way for new therapeutic strategies.
Breakthrough in skeletal muscle regeneration
In a finding that opens the door to the development of targeted therapies for various muscle disorders, newly published research identifies key mechanisms of skeletal muscle regeneration and growth of muscles following resistance exercise.
All stem cell therapies are not created equal
Researchers have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells.
Stem cell-derived therapy shows promise against treatment-resistant liver cancer
New research shows how stem cell-derived therapy, targeting treatment-resistant liver cancer through genetically modified NK cells, offers promising new avenues for immunotherapy.
Study points at novel approach to treat Group 3 medulloblastoma
A team of researchers has identified and located a population of stem-like cells that initiates and maintains Group 3 medulloblastoma (Gr3-MB) in the developing brain. Gr3-MB is one of the most aggressive forms of brain cancer in children and is associated with metastatic spread and poor survival. The researchers showed that eliminating the small population of stem-like cells present in Gr3-MB tumors led to tumor shrinkage in preclinical models. Although more research is needed, this novel approach may lead to new ways to treat children with Gr3-MB.
Important step forward in stem cell therapy for rare bowel disease
A new study has demonstrated the potential of stem cell therapy to treat those with Hirschsprung disease.
Fertility treatments could get boost from stem cells
An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice.
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